Journal Article and Summary

Article: Effectiveness of Antiseizure Medications Therapy in Preventing Seizures in Brain Injury Patients: A Network Meta-Analysis

Citation: Huo, Xianhao, et al. “Effectiveness of Antiseizure Medications Therapy In Preventing Seizures In Brain Injury Patients: A Network Meta-Analysis.” Frontiers in Pharmacology, vol. 13, 15 Sept. 2022,

  • Traumatic brain injury (TBI) is mainly caused by direct or indirect external forces on the head. More than 50 million people worldwide suffer from TBI each year. These injuries can result in various disabilities, including neurological deficits, memory loss, and other negative results, making TBI a chronic health condition and a global healthcare burden.

  • Post-traumatic epilepsy (PTE) is a recognized complication of TBI. Depending on the location and severity of the bleeding, PTE can occur immediately within 24 h after trauma, early within the first 7 days following trauma, and late after 7 days following trauma.

  • Over the past 30 years, the cumulative incidence of PTE was 2% for mild brain injury, 4% for moderate brain injury, and 15% for severe brain injury. Prophylactic treatment with anti-seizure medications is increasingly being used to reduce the risk of developing PTE following TBI.

  • In order to assess the efficiency of anti-seizure drugs in avoiding early or late seizures in TBI patients, a ranked network meta-analysis was conducted in this study. They also assessed the mortality rate and unfavorable side effects associated with the various regimens.